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Also known as Prempro, Premphase, Prempro Low Dose.   Premphase (Oral) is used for the Treatment of Conjugated Estrogens (KON-joo-gated ES-troe-jenz), Medroxyprogesterone Acetate (me-DROKS-ee-proe-JES-te-rone AS-a-tate).   It also treats lack of estrogen and progestin in your body caused by menopause or removal of the ovaries and helps prevent osteoporosis (weak and brittle bones). This drug is a combination of hormones.

You should not use this drug if you have had an allergic response to estrogen or progestin, or if you have had a hysterectomy. You should not use this medication if you have any abnormal vaginal bleeding, blood clots, circulation problems, liver disease, cancer of the breast or uterus, or if you have had a stroke. Do not use this medication if you are pregnant or breastfeeding.


  • Taking this medicine while you are pregnant can hurt your unborn baby. Use an effective form of birth control to remain from getting pregnant. If you think you have become pregnant while taking the medication, tell your physician right away.
  • Inform your physician if you have diabetes, high blood pressure, high cholesterol, asthma, migraine headaches, seizures, heart failure, or depression, or gall bladder, kidney, or liver disease.
  • Your physician will need to monitor your progress at regular visits while you are taking this medication. Be sure to keep all appointments.
  • Continuing use of large doses of estrogens may amplify your risk of some kinds of cancer, including breast cancer. Your physician should check your breasts for lumps and other changes on a regular schedule. Inspect your breasts at home every month. If you have questions about cancer risks or breast self-examination, talk with your physician.

Premphase (Oral) Side Effects

Call your physician right away if you detect or experience any of these side effects:

  • Abnormal vaginal bleeding
  • Lump in your breast
  • Pain in your chest or lower leg (calf)
  • Severe headache
  • Severe stomach pain or swelling
  • Shortness of breath, coughing up blood
  • Sudden vision changes
  • Weakness or numbness in an arm or leg
  • Yellowing of skin or eyes If you notice these less serious side effects, talk with your doctor:
  • Bloated feeling, weight gain, swelling in hands, feet, or ankles
  • Breast tenderness or swelling
  • Changes in sexual desire
  • Depression, dizziness
  • Mild nausea or vomiting
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