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Zofran Zydis is used to relieve nausea (sick feeling) and vomiting which can take place after certain treatments such as chemotherapy and radiotherapy. Zofran is also used for the prevention of nausea and vomiting, which can come about after a surgical procedure. Zofran Zydis wafers should only be used to treat the nausea and vomiting for which they have been prescribed.

Before you use Zofran Zydis

When you must not use them

  • Do not consume Zofran Zydis if you have ever had an allergic reaction to ondansetron.
  • Do not use Zofran Zydis after the expiration date printed on the pack. If you take it after the expiration date it may not work as it should.
  • Do not use Zofran Zydis if the wrapping is torn or shows signs of tampering or if the wafers look damaged or discolored.

Before you take Zofran Zydis

  • Inform your physcian if you are pregnant, trying to become pregnant or breast-feeding. Your physician can discuss the hazards and benefits of taking Zofran Zydis with you.
  • If you have had to stop taking another medication for your nausea or vomiting, inform your physician.
  • If you are allergic to any foods, dyes, preservatives or any other medications, inform your physician.
  • If you have or previously had liver problems, inform your physician
  • Inform your physician if you are constipated
  • If you have a condition called phenylketonuria because Zofran Zydis contain aspartame.

Taking other medicines

Inform your physician the names of any medications you are taking, including those you buy over the counter from a pharmacy, supermarket or health food shop.

Especially, inform your physician if you are taking:

  • Carbamazepine (TegretolT, TerilT) - a medication for epilepsy, bipolar disorder and some pain conditions
  • Rifampicin (RifadinT, RifanahT) - an antibiotic used for tuberculosis and other infections
  • Phenytoin (DilantinT) - a medicine for epilepsy
  • Tramadol (TramalT, ZytramT) - a medicine for pain

Some medications may influence the way other medicines work. Your physician or pharmacist will be able to tell you what to do when taking Zofran with other medicines.

How to take Zofran

The Pharmacist's label on the package will inform you how many Zofran Zydis wafers to take and how often to take them. If there is anything that you do not comprehend, ask your physician or pharmacist.

DO NOT take MORE Zofran Zydis than your physician or pharmacist tells you.

If you vomit within one hour of taking your first Zofran Zydis wafer of each course prescribed for you, you should take the same dose again. If you continue to vomit, inform your physician.

If you skip a dose or forget to take your medication, take it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medication to make up for a missed dose.

Things to be careful of

  • Do not give your Zofran Zydis to anyone else.
  • Only take your Zofran Zydis for the reason they have been prescribed. Do not use them for anything else, including nausea from other causes.
  • Zofran should not affect your ability to drive or operate machinery.


Like all medications, Zofran Zydis could cause some side effects. Sometimes they are serious, most of the time they are not. Your physician or pharmacist will be able to answer any questions you may have.

Inform your physician if you notice any of the following side effects:

  • Headache
  • A sensation of warmth or flushing
  • Constipation
  • Hiccups.

These are all mild side effects. There is no immediate reason to stop taking your medication unless you are concerned.

Inform your physician immediately or go to your nearest Accident and Emergency department if you notice any of the following side effects:

  • 'Wheezy' symptoms
  • Chest pain or tightness of chest
  • Changes in the way your heart beats eg if you notice it beating faster or slower than normal, or if it beats irregularly or if it 'throbs'
  • Low blood pressure
  • Fits or convulsions
  • Swelling of the eyelids, face, lips, mouth or throat which may cause difficulty in swallowing or breathing
  • Skin rash, skin lumps or hives
  • Problems with muscles or movement.