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Tamoxifen aka, Nolvadex Side Effects Causing Blood Clots in the Lung and Uterine Cancer.

Researchers have linked Tamoxifen with ischemic stroke risk, according to the journal Neurology. There is high risk of additional strokes among patients taking the drug for five years or more, according to study co-author Cheryl D. Bushnell, MD.

Nolvadex (tamoxifen citrate) users risks include uterine malignancies, stroke, and pulmonary emboli, some of which have been fatal. In clinical trials, uterine malignancies, including endometrial cancer and uterine sarcomas (from "WARNINGS, Effects on the Uterus, Endometrial Cancer and Uterine Sarcoma", in full Prescribing Information), and venous thrombotic events, including pulmonary emboli, occurred 2 to 4 times more often with NOLVADEX than placebo, but each in less then 1% of women. Stroke, cataracts, and cataract surgery also occurred more often with Nolvadex.

Tamoxifen has been taken by millions of women over 30 years and risk/benefit issues are often debated. Tamoxifen can behave as estrogen in some tissue; it can increase the risk of blood clot and cancer.

It has been unclear whether Tamoxifen use increases a woman's stroke risk. A recently published review of studies showed almost a 50% increase in the risk of all types of stroke, but Bushnell and colleague Larry Goldstein, MD, of Duke University Medical Center guessed the risk of blood clot-related strokes might be higher.