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Due to serious safety concerns regarding Serzone, current or prospective patients may search for a Serzone substitute. Serzone (nefazodone) is an antidepressant drug belonging to a strain of drugs known as phenylpiperazine. This medication was approved by the FDA in December 1994 and manufactured by Bristol-Meyers Squibb. Serzone is a medication that is chemically unrelated to many other antidepressant drugs.

Serzone has been confirmed to cause serious damage to the liver. Serzone has caused twenty six deaths due to Serzone-induced liver failure. Because Serzone patients are three to four times more likely to suffer liver failure than the general population, this drug was taken off all European and Canadian drug markets in January 2003. In May 2004 Serzone was taken off the market, though it is still available in generic form. Because of these serious risks and the 2004 recall, Serzone replacement medications must be considered for patients seeking antidepressant medication therapy.

Individuals should discuss Serzone substitute with their doctors as there are many alternative prescription drugs that can provide benefits similar to Serzone, but without the risk of harmful side effects. All antidepressant Serzone replacement medications have their own set of risks and benefits; thus it is important to speak to your physician about your medical history, present condition, and all other significant issues before settling on which Serzone replacement is right for you.

Antidepressant drugs act on the neurotransmitter chemicals in the brain in order to decrease the adverse symptoms of depression and some other psychological conditions. Tricyclics are antidepressants that have been used to treat depression for decades and may be good options for Serzone replacement. Tricyclics work on serotonin and norepinephrine and other chemicals in the body. Examples of these Serzone replacement medications consist of: Elavil, Norpramin, Tofranil, Aventyl, and Pamelor. These Serzone replacement alternatives all have benefits and side effects that should be well thought-out to decide if these medications are suitable for you. This class of medication is connected to blood pressure and heart rate problems. Common side effects from these Serzone replacement medications include, but are not limited to: dry mouth, blurred vision, constipation, worsening of glaucoma, impaired thinking, fatigue, and problems urinating.

SRRIs or Selective Serotonin Reuptake Inhibitors are an additional class of antidepressants that may be taken into account when looking for a Serzone replacement. These medications affect only serotonin chemicals in the brain, which may translate into a lower risk of side effects compared to tricyclics. Lexapro, Celexa, Prozac, Paxil, and Zoloft are all examples of SSRI antidepressant Serzone replacement options. These medications are also associated with certain risks and benefits that should be discussed with a medical professional. These medications cannot be taken in conjunction with other drugs, especially MAOIs, or Monoamine Oxidase Inhibitors, which are also potential Serzone replacement drugs. There are a number of other antidepressant medications which may prove to be possible Serzone replacement options. If you are interested in learning more about a Serzone replacement, you should speak with your health care provider.