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Celexa

Celexa was offered to the public in 1999 and is manufactured in Ireland by Forest Pharmaceuticals. The drug is a recent one belonging to the group of antidepressants identified as SSRIs (selective serotonin reuptake inhibitors).

Since the federal Food and Drug Administration has not permitted the use of Celexa for pediatric depression, Forest is officially banned from endorsing them for such uses. However, physicians are permitted to administer drugs off-label where they see fit and Celexa is the fourth largely given medication for pediatric depression.

Forest Laboratories received a wide-ranging request from the New York attorney general, Eliot Spitzer, asking for information about how the company tested and promoted drugs like its antidepressant Celexa for so-called off-label, or as yet unapproved, uses.

Mr. Spitzer's action follows an article in The New York Times which disclosed that Forest did not tell a medical journal about a unsuccessful, unpublicized trial of Celexa in children and adolescents when it published an article about a positive trial of the same medications in the same types of individuals.